from defects in insulin secretion, or action, or both.
Diabetes Mellitus, commonly referred to as diabetes was first identified as a
disease associated with “sweet urine” and excessive muscle loss in the
ancient world. Elevated levels of blood glucose (hyperglycemia) lead to
spillage of glucose into the urine, hence the term sweet urine.
Normally, blood glucose levels are tightly controlled by insulin, a
hormone produced by the pancreas. Insulin lowers the blood glucose
level. When the blood glucose elevates (for example, after eating food),
insulin is released from the pancreas to normalize the glucose level.
In patients with
diabetes, the absence or insufficient production of
insulin causes hyperglycemia.